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Clinical and symptom measures

G T O'Connor1, S T Weiss

  • 1Pulmonary Center, Boston University School of Medicine, MA 02118.

American Journal of Respiratory and Critical Care Medicine
|February 1, 1994
PubMed
Summary
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This review evaluates health status measures for asthma research. Questionnaires are useful for epidemiology, but clinical research needs better symptom severity assessments. Physical exams and lab tests have limited utility.

Area of Science:

  • Pulmonary Medicine
  • Epidemiology
  • Clinical Research Methodology

Background:

  • Assessing asthma presence and severity is crucial for both epidemiologic and clinical research.
  • Existing health status measures, including symptoms, physical exams, and lab tests, vary in their suitability.
  • Lung function tests are excluded from this review's scope.

Purpose of the Study:

  • To review the validity, reliability, and responsiveness of specific health status measures for asthma assessment.
  • To identify suitable measures for epidemiologic research and clinical trials.
  • To highlight limitations of current measures in capturing asthma severity.

Main Methods:

  • Review of existing literature on health status measures for asthma.
  • Focus on questionnaires, physical examination findings, and laboratory tests (excluding lung function).

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  • Evaluation of measures based on validity, reliability, and responsiveness to intervention.

    • Main Results:

    • Validated adult and childhood questionnaires exist for epidemiologic research on asthma and wheezing.
    • These questionnaires lack sufficient detail on symptom severity for clinical research in established asthma.
    • Physical examination findings and most laboratory tests (e.g., chest X-ray) have limited utility as asthma outcome measures.

    Conclusions:

    • Specific questionnaires demonstrate reliability and validity for asthma epidemiology.
    • Current measures are insufficient for assessing asthma symptom severity in clinical research.
    • Further development is needed for robust clinical outcome measures in asthma trials.