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The goat as a model for Corynebacterium renale pyelonephritis
S Elias1, B Abbas, S M el San-Ousi
1Department of Veterinary Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, Sudan.
The British Veterinary Journal
|September 1, 1993
Summary
Nubian goats experimentally infected with Corynebacterium renale developed anorexia, weight loss, and urinary abnormalities. This study evaluates the goat as a model for bovine pyelonephritis.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Animal Models
Background:
- Corynebacterium renale type II causes pyelonephritis in cattle.
- The Nubian goat is a potential animal model for studying this disease.
Purpose of the Study:
- To investigate the experimental infection of Nubian goats with Corynebacterium renale type II.
- To assess the clinical, clinicopathological, and pathological changes following infection.
- To evaluate the suitability of the goat as a model for bovine C. renale pyelonephritis.
Main Methods:
- Nubian goats were infected with C. renale type II via intravenous or intraurethral routes.
- Different infection doses were used: 1.75 x 10(10), 7.08 x 10(19), or 5 x 10(23) organisms.
- Clinical signs, urine analysis, serum biochemistry, hematology, and post-mortem examinations were performed.
Main Results:
- Infected goats exhibited anorexia, weight loss, depression, albuminuria, pyuria, and epithelial casts.
- Intravenous challenge led to dose-related increases in serum ammonia, urea, and creatinine.
- Post-mortem findings included cystitis, urethritis, nephrosis, and renal pelvis discharge.
Conclusions:
- Experimental C. renale type II infection in Nubian goats induces significant clinical and pathological changes.
- The observed effects support the Nubian goat's utility as a model for bovine pyelonephritis.
- Further research can leverage this model to understand C. renale pathogenesis and develop treatments.