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Benzodiazepines antagonize central corticotropin releasing hormone-induced suppression of natural killer cell
M Irwin1, R L Hauger, K Britton
1Department of Psychiatry, University of California at San Diego.
Brain Research
|December 17, 1993
Abstract:
Benzodiazepines have anxiolytic properties and attenuate behavioral stress responses induced by corticotropin releasing hormone (CRH). To evaluate the effect of benzodiazepines on CRH-induced immune suppression, potent centrally acting benzodiazepines were administered prior to central infusion of CRH (i.c.v.; 1.0 microgram). CRH induced a significant (P < 0.01) reduction of splenic natural killer cell activity which was completely antagonized by pretreatment with either diazepam or alprazolam.