[Cephalothin and platelet enzymes in chronic renal failures]

Cephalothin inhibits the activities of platelet enzymes, succinic dehydrogenase and NADH-cytochrome-c-reductase in patients with chronic renal failure. Two hours after Cephalothin administration the return of enzyme activities to baseline values was dependent on the severity of the chronic renal failure, and the higher the serum-creatinine concentration, the slower was the return to original enzyme activities.