Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoglycemia unawareness in IDDM

P E Cryer1

  • 1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

Diabetes Care
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Hypoglycemia unawareness in type 1 diabetes results from autonomic failure, increasing risks for severe hypoglycemia. Recurrent hypoglycemia may worsen symptoms and defenses, creating a dangerous cycle.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventing hypoglycaemia: what is the appropriate glucose alert value?

Diabetologia·2008
Same author

Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711-1721.

Diabetologia·2006
Same author

Hypoglycaemia: the limiting factor in the glycaemic management of the critically ill?

Diabetologia·2006
Same author

The pathophysiology of hypoglycaemia in diabetes.

Diabetes, nutrition & metabolism·2003
Same author

Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes.

Diabetologia·2002
Same author

Hypoglycemia-associated autonomic failure in diabetes.

American journal of physiology. Endocrinology and metabolism·2001

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetes Mellitus Research

Background:

  • Hypoglycemia unawareness, a loss of autonomic warning symptoms, is a key feature of hypoglycemia-associated autonomic failure in individuals with type 1 diabetes (IDDM).
  • This condition, along with defective glucose counterregulation and elevated glycemic thresholds, significantly elevates the risk of severe iatrogenic hypoglycemia.
  • The exact causes of these syndromes remain largely unknown and are considered multifactorial.

Purpose of the Study:

  • To explore the clinical syndromes associated with hypoglycemia-associated autonomic failure in type 1 diabetes.
  • To identify risk factors contributing to severe iatrogenic hypoglycemia in IDDM patients.
  • To investigate the potential role of antecedent hypoglycemia in the pathogenesis of recurrent severe hypoglycemia.

Related Experiment Videos

Main Methods:

  • This study focuses on analyzing clinical syndromes and risk factors related to hypoglycemia in individuals with type 1 diabetes.
  • The research examines the relationship between hypoglycemia unawareness, defective glucose counterregulation, and glycemic thresholds.
  • Pathogenesis is explored through observational analysis of patient data and clinical presentations.

Main Results:

  • Hypoglycemia unawareness and related syndromes are major risk factors for severe iatrogenic hypoglycemia in type 1 diabetes.
  • Recent antecedent hypoglycemia appears to be a significant factor in the development of recurrent severe hypoglycemia.
  • This antecedent hypoglycemia may reduce both warning symptoms and defensive responses, creating a vicious cycle of severe hypoglycemic events.

Conclusions:

  • Hypoglycemia unawareness and associated syndromes represent a critical challenge in managing type 1 diabetes.
  • Recurrent iatrogenic hypoglycemia is a significant risk factor for future severe hypoglycemic episodes, potentially due to impaired symptom recognition and counterregulatory responses.
  • While antecedent hypoglycemia plays a role, treatment with human versus animal insulin does not seem to be a major contributing factor to these syndromes.