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Related Experiment Videos

Opioid-dopaminergic interactions in primary empty sella

A Mancini1, G Conte, C Fiumara

  • 1Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy.

Experimental and Clinical Endocrinology
|January 1, 1993
PubMed
Summary
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This study investigated neurotransmitter abnormalities in primary empty sella (PES) patients. Opiate receptor blockade revealed altered prolactin (PRL) and growth hormone (GH) secretion, suggesting modified dopaminergic and opiatergic neuron interactions in PES.

Area of Science:

  • Neuroendocrinology
  • Pituitary Disorders
  • Hormone Secretion Regulation

Background:

  • Primary empty sella (PES) is associated with abnormal prolactin (PRL) secretion.
  • Endogenous opiates and dopamine are known to interact in modulating PRL secretion.

Purpose of the Study:

  • To investigate neurotransmitter abnormalities in PES by examining the effect of opiate receptor blockade.
  • To assess the impact of Naloxone (NAL) on anterior pituitary hormones and PRL responsiveness to metoclopramide (MCP) in PES patients.

Main Methods:

  • Studied 10 premenopausal normoprolactinemic PES patients in the follicular phase.
  • Administered Naloxone (NAL) as a continuous infusion (1.6 mg/h).
  • Measured anterior pituitary hormones (LH, FSH, PRL, GH) and PRL response to metoclopramide (MCP).

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Main Results:

  • NAL did not significantly alter basal LH and FSH levels.
  • NAL caused slight but significant increases in PRL and GH secretion.
  • NAL partially blunted the enhanced PRL response to metoclopramide observed in PES patients.

Conclusions:

  • Hormone secretion modulation differs in PES patients compared to normal subjects.
  • NAL induced a paradoxical increase in PRL and GH, suggesting altered opiate pathway function.
  • NAL blocked the exaggerated PRL response to dopaminergic blockade, indicating modified dopaminergic-opiatergic neuron relationships in PES.