Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...

Hypertension IV: Drug Therapy and Lifestyle Modifications

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...

Antihypertensive Drugs: Potassium-Sparing Diuretics

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...

Antihypertensive Drugs: Direct Renin Inhibitors

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spectrum of potentially lethal cardiac conditions presenting with fetal sinus bradycardia: a report on 34 cases.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026

Same author

Navigating Adversity: Non-Completion and Evacuation of Trail Runners at the 2022 Magoebaskloof Forest Marathon.

South African journal of sports medicine·2026

Same author

A Descriptive Evaluation of Evidence-Based Rounds in Critical Care Using Mixed Data Types.

Journal of advanced nursing·2025

Same author

Predicting histopathological features of aggressiveness in lung cancer using CT radiomics: a systematic review.

Clinical radiology·2024

Same author

Temporal evolution of chest radiographic appearances in COVID-19 with clinicoradiological associations: a multicentre United Kingdom resident-led study.

Clinical radiology·2024

Same author

Food system actor perspectives on future-proofing European food systems through plant breeding.

Scientific reports·2023

Search research articles

Related Experiment Videos

Primary hyperaldosteronism--diagnostic approach and management

M S Seshadri¹, A S Kanagasabapathy, A M Cherian

¹Christion Medical College & Hospital, Vellore.

The Journal of the Association of Physicians of India

|May 1, 1993

Summary

This summary is machine-generated.

Primary hyperaldosteronism, a cause of secondary hypertension, was found in 1% of patients. Hypokalemia and specific CT scans aided diagnosis, with medications effectively managing hypertension and hypokalemia.

Related Experiment Videos

Area of Science:

Endocrinology
Nephrology
Cardiology

Background:

Secondary hypertension affects a significant patient population.
Primary hyperaldosteronism is an underdiagnosed cause of secondary hypertension.
Early detection and management are crucial for patient outcomes.

Purpose of the Study:

To determine the prevalence of primary hyperaldosteronism in patients with secondary hypertension.
To identify key diagnostic clues for primary hyperaldosteronism.
To evaluate the efficacy of medical management for primary hyperaldosteronism.

Main Methods:

Retrospective analysis of patients evaluated for secondary hypertension.
Assessment of serum potassium and 24-hour urine potassium levels.
Utilization of high-resolution CT scans for adrenal tumor localization.
Preoperative and long-term medical management with nifedipine and spironolactone.

Main Results:

Primary hyperaldosteronism detected in 1% of patients with secondary hypertension.
Hypokalemia with inappropriate kaliuresis (24 hr. urine K > 20mEq) served as a key diagnostic indicator.
High-resolution CT scans effectively localized adrenal tumors.
Nifedipine and spironolactone demonstrated efficacy in preoperative and long-term management of hypertension and hypokalemia.

Conclusions:

Primary hyperaldosteronism is a relevant diagnosis in patients presenting with secondary hypertension.
Clinical and biochemical parameters, alongside imaging, are vital for diagnosis.
Pharmacological interventions, including nifedipine and spironolactone, provide effective control for both adrenal adenoma and bilateral adrenal hyperplasia.