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Short course ciprofloxacin therapy for enteric fever

D Mathai1, G C Kudva, J S Keystone

  • 1Department of Medicine, Christian Medical College and Hospital, Vellore, India.

The Journal of the Association of Physicians of India
|July 1, 1993
PubMed

Insights

A short course of ciprofloxacin effectively treated enteric fever in 21 patients. Most patients responded quickly, with Salmonella bacteria cleared from stools, though some experienced recurrence.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is a significant global health concern.
  • Antibiotic resistance is a growing challenge in treating enteric fever, necessitating effective treatment options.

Purpose of the Study:

  • To evaluate the efficacy and safety of a short course of ciprofloxacin for treating uncomplicated enteric fever.
  • To assess the microbiological response and clinical outcomes in patients receiving ciprofloxacin therapy.

Main Methods:

  • A prospective study involving 21 hospitalized patients diagnosed with S. typhi or S. paratyphi A infection.
  • Patients received ciprofloxacin 750 mg twice daily for 7 days.
  • Clinical response (fever resolution), microbiological clearance (stool cultures), and recurrence rates were monitored.

Main Results:

  • Ciprofloxacin demonstrated high efficacy, with a median fever response time of 3 days.
  • All Salmonella isolates were susceptible to ciprofloxacin, with low minimum inhibitory concentrations (MICs).
  • Stool cultures were negative for Salmonella during follow-up (11-24 weeks), but two patients experienced recurrence.

Conclusions:

  • A short course of ciprofloxacin is an effective treatment for uncomplicated enteric fever caused by susceptible S. typhi and S. paratyphi A.
  • Close monitoring for recurrence is recommended following ciprofloxacin therapy for enteric fever.

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