Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipid modification during epidermal cell differentiation

G A Thompson1

  • 1Department of Botany, University of Texas, Austin 78713-7640.

The Journal of Dermatology
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis.

Alimentary pharmacology & therapeutics·2016
Same author

Ether-containing lipids of the slime mold,Physarum polycephalum: I. Characterization and quantification.

Lipids·2016
Same author

Ether-containing lipids of the slime mold,Physarum polycephalum: II. Rates of biosynthesis.

Lipids·2016
Same author

Search for a two-Higgs-boson doublet using a simplified model in pp collisions at sqrt[s] = 1.96 TeV.

Physical review letters·2014
Same author

Family-centred music therapy to promote social engagement in young children with severe autism spectrum disorder: a randomized controlled study.

Child: care, health and development·2013
Same author

Increased 5-enolpyruvylshikimic acid 3-phosphate synthase activity in a glyphosate-tolerant variant strain of tomato cells.

Plant cell reports·2013
Same journal

Risk Factors for Cutaneous Immune-Related Adverse Events in the Japanese Population: A Retrospective Single-Center Cohort Study.

The Journal of dermatology·2026
Same journal

Characterization of Prurigo Nodules in Adults With Moderate-To-Severe Atopic Dermatitis in Japan: A 2-Year Observational Study.

The Journal of dermatology·2026
Same journal

Real-World Effectiveness of Tildrakizumab in Japanese Patients With Psoriasis: Analyses Stratified by Prior Systemic Therapy, Maintenance of Early Responses, and Achievement of Delayed Responses.

The Journal of dermatology·2026
Same journal

Clinical Characteristics and Treatment Patterns of Hyperhidrosis in Northern Hokkaido: A Single-Center Retrospective Descriptive Study.

The Journal of dermatology·2026
Same journal

Sparing of the Nipple-Areolar Complex and Periareolar Skin as a Diagnostic Clue for Radiation-Induced Morphea of the Breast.

The Journal of dermatology·2026
Same journal

Bullous Pemphigoid With Blister Sparing in Areas of Neurologic Impairment Caused by Syringomyelia.

The Journal of dermatology·2026
See all related articles

Skin keratinocytes undergo lipid modification during differentiation to form the epidermal barrier. This process involves targeting membrane lipids to lamellar bodies for transformation into intercellular lamellae, crucial for barrier function.

Area of Science:

  • Skin biology
  • Cellular lipid metabolism
  • Epidermal barrier formation

Background:

  • Keratinocytes differentiate into corneocytes, forming the skin's primary permeability barrier.
  • Lipid composition undergoes significant changes during keratinocyte differentiation to serve barrier functions.

Purpose of the Study:

  • To elucidate the molecular mechanisms behind lipid modification during keratinocyte differentiation.
  • To understand how membrane-derived lipids are processed for the epidermal permeability barrier.

Main Methods:

  • Investigated the targeting of membrane lipids to specialized lamellar bodies.
  • Analyzed the metabolic alterations of lipids within lamellar bodies.
  • Examined the covalent interactions between modified lipids and proteins in intercellular lamellae.

Related Experiment Videos

Main Results:

  • Clarified molecular mechanisms for lipid targeting to lamellar bodies.
  • Demonstrated metabolic retailoring of lipids for intercellular lamellar structures.
  • Revealed lipid-protein interactions promoting lipid bilayer and monolayer formation.

Conclusions:

  • Lipid modification is essential for epidermal barrier integrity.
  • The molecular regulation of this lipid transformation is beginning to be understood.
  • Further research into lipid regulation will enhance understanding of skin barrier function.