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Ultrastructural observation of epithelioid sarcoma
1Division of Dermatology, Tokyo Medical College, Kasumigaura Hospital, Ibaraki, Japan.
The Journal of Dermatology
|November 1, 1993
Summary
This study investigated an epithelioid sarcoma in a 58-year-old female, revealing unique cellular structures and potential fibrous necrosis. Findings contribute to understanding sarcoma morphology and tumor cell degeneration.
Area of Science:
- Oncology
- Pathology
Background:
- Epithelioid sarcoma is a rare soft tissue sarcoma with uncertain differentiation.
- Understanding its histological and ultrastructural features is crucial for diagnosis.
Observation:
- Microscopic examination revealed light and dark tumor cells with extracellular and intracellular eosinophilic bodies.
- Intercellular bodies were PAS positive and diastase resistant, while extracellular bodies were not.
- Ultrastructural analysis showed tumor cells with microfilaments, lipid droplets, and a reticulogranular structure.
Findings:
- Tumor cells expressed vimentin, keratin, and partially epithelial membrane antigen.
- Extracellular filamentous bodies, resembling colloid bodies, suggest fibrous necrosis of tumor cells.
- Intracellular eosinophilic bodies were identified as lipid droplets.
Implications:
- These findings enhance the understanding of epithelioid sarcoma's cytological and ultrastructural characteristics.
- The study provides insights into tumor cell degeneration and potential diagnostic markers.
- Further research can refine diagnostic criteria and therapeutic strategies for epithelioid sarcoma.