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Depression and weight gain: the serotonin connection

J J Wurtman1

  • 1Massachusetts Institute of Technology, Cambridge 02139.

Journal of Affective Disorders
|October 1, 1993
PubMed
Summary

Recurrent weight gain is linked to mood disturbances affecting appetite and exercise. Interventions boosting brain serotonin show promise in normalizing mood and food intake, aiding weight management.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Obesity Research

Background:

  • Inability to control food intake and exercise adherence contributes to weight gain.
  • Mood fluctuations (daily, seasonal) can trigger overeating of carbohydrates and reduce physical activity.
  • Brain serotonin is implicated in mood and appetite regulation.

Purpose of the Study:

  • To explore the role of brain serotonin in mood-related appetite and weight gain.
  • To investigate the efficacy of interventions targeting serotoninergic activity for weight management.

Main Methods:

  • Review of recent studies on dietary and pharmacological interventions.
  • Analysis of the impact of serotoninergic activity modulation on mood and food intake.

Main Results:

  • Increased serotoninergic activity normalizes excessive food intake.
  • Enhanced serotonin levels diminish depressed mood.
  • These interventions show potential for preventing recurrent weight gain.

Conclusions:

  • Maintaining mood and controlling food intake are crucial for preventing weight regain.
  • Periodic or sustained interventions targeting serotonin may be effective.
  • Further research into serotoninergic pathways is warranted for obesity treatment.

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