Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute diffuse leukoencephalitis in HIV-1 infection

W Lüer1, J Gerhards, S Poser

  • 1Department of Neurology, Georg-August University, Göttingen, Germany.

Journal of Neurology, Neurosurgery, and Psychiatry
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Creutzfeldt-Jakob disease: comparative analysis of MR imaging sequences.

AJNR. American journal of neuroradiology·2006
Same author

Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2005
Same author

Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia, and Canada.

Neurology·2005
Same author

Immunoglobulins and virus-specific antibodies in patients with Creutzfeldt-Jakob disease.

Acta neurologica Scandinavica·2005
Same author

Escalating immunotherapy of multiple sclerosis--new aspects and practical application.

Journal of neurology·2004
Same author

Interferon beta-1b modulates serum sVCAM-1 levels in primary progressive multiple sclerosis.

Acta neurologica Scandinavica·2004
Same journal

Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

Journal of neurology, neurosurgery, and psychiatry·2026
See all related articles

Acute diffuse leukoencephalitis in HIV patients can cause severe neurological deficits. Antiretroviral treatment effectively resolved symptoms and improved MRI and CSF markers.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Neuroimmunology

Background:

  • Acute diffuse leukoencephalitis is a rare demyelinating disease.
  • It is associated with human immunodeficiency virus (HIV) infection of the central nervous system.
  • Early diagnosis and intervention are crucial for patient outcomes.

Observation:

  • A previously asymptomatic HIV-positive patient presented with acute tetraparesis.
  • Cerebrospinal fluid analysis revealed inflammatory abnormalities and elevated P24 antigen.
  • Magnetic Resonance Imaging (MRI) demonstrated diffuse white matter hyperintensities.

Findings:

  • The patient's neurological deficits resolved completely within 22 months.
  • Clinical improvement correlated with significant enhancements in MRI findings.

Related Experiment Videos

  • Cerebrospinal fluid inflammatory markers and P24 antigen levels also normalized.

    • Implications:

    • This case highlights the potential for significant neurological recovery in HIV-associated leukoencephalitis.
    • Prompt antiretroviral therapy is effective in managing this condition.
    • Integrated clinical, radiological, and CSF monitoring is essential for assessing treatment response.