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Related Experiment Videos

Quantitative testing of sympathetic function with laser Doppler flowmetry

M A Valley1, D L Bourke, A M McKenzie

  • 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD.

Journal of Clinical Monitoring
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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A new indirect technique using inspiratory gasp vasoconstrictive response (IGVR) effectively evaluates sympathetic nervous system function. This method is suitable for patients with peripheral neuropathy, unlike painful stimuli.

Area of Science:

  • Physiology
  • Autonomic Nervous System Research
  • Medical Technology Development

Background:

  • Assessing dynamic changes in human sympathetic function is crucial for understanding various physiological and pathological states.
  • Current methods for evaluating sympathetic activity can be invasive or limited in their applicability to certain patient populations.

Purpose of the Study:

  • To develop and validate a novel, indirect technique for assessing sympathetic efferent function in humans.
  • To compare the efficacy of an inspiratory gasp maneuver with established provocative stimuli for eliciting vasoconstrictive responses.

Main Methods:

  • Laser Doppler was employed to measure skin perfusion changes on the thenar eminence in 10 healthy subjects.
  • Three stimuli were used: inspiratory gasp (IG), ice-water immersion (Ice), and pin prick (Pin), with 10 trials each.

Related Experiment Videos

  • Vasoconstrictive response (VR) and baseline perfusion variation were quantified for each stimulus.

    • Main Results:

    • The inspiratory gasp maneuver (IGVR) elicited a significant vasoconstrictive response (54.1 ± 2.3%), comparable to ice-water immersion (49.2 ± 2.0%).
    • The pin prick stimulus produced a lower response (24.0 ± 1.8%) and was often perceived as painful.
    • IGVR was not dependent on noxious input, making it suitable for patients with peripheral neuropathy.

    Conclusions:

    • The inspiratory gasp vasoconstrictive response (IGVR) is a sensitive and non-noxious indirect method for evaluating sympathetic efferent function.
    • This technique offers a valuable alternative for assessing sympathetic function in clinical settings, particularly in patients with conditions like diabetes mellitus.
    • The IGVR technique has potential for broader applications in monitoring autonomic nervous system health.