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Experience with pediatric lung transplantation

B E Noyes1, G Kurland, D M Orenstein

  • 1Children's Hospital of Pittsburgh, Pennsylvania.

The Journal of Pediatrics
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

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Pediatric heart-lung and lung transplants show encouraging survival rates, with most young patients resuming active lives post-procedure. Challenges include infection and rejection, but the surgery offers a life-saving option for end-stage cardiopulmonary disease.

Area of Science:

  • Cardiology
  • Pulmonology
  • Pediatric Surgery

Background:

  • Heart-lung and lung transplantation are established treatments for adult end-stage cardiopulmonary disease.
  • Pediatric transplantation data is less common, necessitating evaluation of outcomes in younger populations.

Purpose of the Study:

  • To report the experience and outcomes of heart-lung and lung transplantation in pediatric patients.
  • To assess the feasibility and survival rates of these procedures in children.

Main Methods:

  • Retrospective review of 34 pediatric patients (<20 years) undergoing heart-lung (n=18) or lung transplantation (n=17) between July 1985 and March 1993.
  • Analysis of indications, survival rates, causes of mortality, and post-transplant morbidity.

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Main Results:

  • Twenty-six patients (76%) survived 1-88 months post-transplant, with most returning to an active lifestyle.
  • Common indications included cystic fibrosis, congenital heart disease with Eisenmenger complex, and primary pulmonary hypertension.
  • Mortality causes included infections (4), multiorgan failure (2), post-transplant lymphoproliferative disease (1), and donor organ failure (1).

Conclusions:

  • Heart-lung and lung transplantation are encouraging, life-saving procedures for pediatric patients with end-stage cardiopulmonary disease.
  • Despite significant morbidity from infection, rejection, and allograft dysfunction, survival and quality of life improvements are notable.
  • Further research and management strategies are needed to mitigate complications and improve long-term outcomes.