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Varicella in children with perinatally acquired human immunodeficiency virus infection
1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30303.
Insights
Children with human immunodeficiency virus infection experienced uncomplicated varicella (chickenpox). Many showed a significant antibody response to varicella-zoster virus, suggesting a robust immune reaction despite HIV.
Area of Science:
- Pediatrics
- Immunology
- Infectious Diseases
Background:
- Perinatally acquired human immunodeficiency virus (HIV) infection can impact immune responses.
- Varicella (chickenpox) is a common childhood illness that can have severe complications in immunocompromised individuals.
Purpose of the Study:
- To evaluate the clinical course and immune response to varicella in children with perinatally acquired HIV infection.
Main Methods:
- Retrospective review of 13 children with HIV and varicella.
- Collection of clinical and epidemiological data, including treatments used.
- Serological testing for antibodies to varicella-zoster virus.
Main Results:
- All 13 children with HIV experienced an uncomplicated clinical course of varicella.
- A significant antibody response to varicella-zoster virus was observed in many of these children.
- No severe complications were reported during the varicella infection in this cohort.
Conclusions:
- Children with perinatally acquired HIV infection may experience a mild course of varicella.
- A notable antibody response to varicella-zoster virus is possible in HIV-infected children.
- Further research is warranted to understand the long-term implications.
Abstract:
Thirteen children with human immunodeficiency virus infection acquired perinatally and with varicella were identified. Clinical and epidemiologic information, including the use of varicella immune globulin and acyclovir, was obtained and testing for antibodies to varicella-zoster virus was done. The 13 children infected with human immunodeficiency virus had an uncomplicated clinical course, and many had a significant antibody response to varicella-zoster virus.