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Staphylococcus saprophyticus sepsis related to total parenteral nutrition admixtures contamination
J M Llop1, I Mangues, J L Pérez
1Department of Pharmacy, Ciudad Sanitaria de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Abstract:
The aim of this study was to report an outbreak of sepsis related to contamination of total parenteral nutrition (TPN) admixtures with Staphylococcus saprophyticus. A total of four patients developed fever after administration of contaminated TPN. Results of cultures of blood, catheter hubs and tips, and TPN admixtures are presented. The strain responsible for the outbreak was able to grow in vitro in two common TPN formulations.
Insights
A Staphylococcus saprophyticus outbreak caused sepsis in four patients due to contaminated total parenteral nutrition (TPN) admixtures. This pathogen demonstrated growth in common TPN formulations, highlighting a critical contamination risk.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Sepsis is a life-threatening condition often associated with healthcare-associated infections.
- Total Parenteral Nutrition (TPN) is a critical intervention for patients unable to receive enteral nutrition.
- Contamination of TPN admixtures poses a significant risk for patient safety.