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Long-term prognosis in 990 medically treated Japanese patients with coronary artery disease
S Nishiyama1, K Kato, S Nakanishi
1Cardiovascular Center, Toranomon Hospital, Tokyo, Japan.
Insights
Japanese patients with coronary artery disease show a favorable prognosis. This study tracked 990 individuals, revealing higher survival rates compared to Western cohorts, offering valuable data for future research.
Area of Science:
- Cardiology
- Epidemiology
- Public Health
Background:
- Coronary artery disease (CAD) poses a significant global health challenge.
- Understanding long-term outcomes in diverse populations is crucial for effective treatment strategies.
Purpose of the Study:
- To analyze the long-term prognosis of medically treated Japanese patients with coronary artery disease.
- To establish a benchmark for future cardiovascular research in Japan and internationally.
Main Methods:
- Retrospective analysis of 990 Japanese patients diagnosed with significant coronary artery disease via angiography.
- Follow-up duration averaged 9.4 years (range: 6.5–17.0 years).
Main Results:
- Overall 5- and 10-year survival rates were 92.1% and 84.4%, respectively.
- Survival rates varied by disease severity: Single-vessel disease (SVD) had the best prognosis, while triple-vessel disease (TVD) had the lowest.
- Japanese patients demonstrated a more favorable prognosis compared to Western populations.
Conclusions:
- Medically managed coronary artery disease in Japanese patients has a favorable long-term outlook.
- Findings provide essential control data for comparative studies on coronary artery disease outcomes.
- This study highlights potential ethnic differences in cardiovascular disease prognosis.
Abstract:
We performed a retrospective analysis of the fate of 990 medically treated Japanese patients with coronary artery disease. Patients were enrolled in this study between September 1973 and February 1984. They were confirmed to have significant coronary artery disease by coronary angiography. There were 924 males and 66 females with a mean age of 54.4 years. The mean duration of follow-up was 9.4 years with a range of 6.5 to 17.0 years. The 5-year and 10-year survival rates for the entire population were 92.1% and 84.4%. The 5-year and 10-year survival rates in patients with single- (SVD), double- (DVD), and triple-vessel disease (TVD) and left main trunk (LMT) disease were as follows: 96.0% and 91.9% for SVD, 93.8% and 87.5% for DVD, 83.2% and 68.3% for TVD, and 89.3% and 84.6% for LMT disease. This was the first large follow-up study of coronary artery disease in Japan. Its results suggest that the prognosis of Japanese patients with coronary artery disease is more favorable than that of patients in Western countries. In addition, the findings should provide a control data base for future studies in Japan and the West.