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Related Experiment Videos

Finite element models for arterial wall mechanics

B R Simon1, M V Kaufmann, M A McAfee

  • 1Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson 85721.

Journal of Biomechanical Engineering
|November 1, 1993
PubMed
Summary

Finite element models (FEMs) simulate arterial mechanics and atherosclerosis. New poroelastic FEMs link arterial wall deformation, fluid motion, and transport for better understanding of physiology and disease.

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Area of Science:

  • Biomechanics
  • Biomedical Engineering
  • Cardiovascular Research

Background:

  • Arterial wall mechanics is crucial for understanding biological structures and designing prosthetics.
  • Biomechanical models, particularly finite element models (FEMs), are vital for studying atherosclerosis, a leading cause of mortality.
  • Existing FEMs have simulated arterial structural response, but lacked direct coupling of transport phenomena with mechanics.

Purpose of the Study:

  • To summarize the applications of FEMs in arterial mechanics.
  • To highlight future research directions in this field.
  • To introduce FEMs based on a poroelastic view of arterial tissues that couple mechanics and transport.

Main Methods:

  • Reviewing the literature on FEM applications in arterial mechanics.

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  • Developing specialized FEMs based on poroelasticity for arterial tissues.
  • Coupling arterial wall deformation, free tissue fluid motion, and associated transport phenomena within the FEM framework.

    • Main Results:

    • FEMs have been extensively used to simulate the structural response of large arteries over the past two decades.
    • A gap exists in models that directly link convective transport in the arterial wall to its mechanics.
    • Poroelastic FEMs offer a framework to integrate mechanics, fluid motion, and transport.

    Conclusions:

    • Poroelastic FEMs provide a pathway to quantitatively link arterial wall mechanics and transport phenomena.
    • This integrated approach is expected to enhance understanding of normal arterial physiology.
    • Such models hold promise for advancing the study of atherogenesis and its underlying mechanisms.