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Vitamin B6 and immune competence

L C Rall1, S N Meydani

  • 1Nutritional Immunology Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.

Nutrition Reviews
|August 1, 1993
PubMed
Summary

Vitamin B6 deficiency impairs immune responses, affecting lymphocytes and antibody production. Supplementation restores function, but high doses offer no added benefit, highlighting the importance of optimal vitamin B6 levels for immunity.

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Area of Science:

  • Immunology
  • Nutritional Science
  • Biochemistry

Background:

  • Vitamin B6 deficiency is linked to compromised immune function in both animal and human studies.
  • Specific immune alterations include impaired lymphocyte differentiation, reduced delayed-type hypersensitivity, and potential indirect effects on antibody production.

Purpose of the Study:

  • To investigate the impact of vitamin B6 status on immune responses.
  • To explore the association between vitamin B6 deficiency and immune changes in specific populations.
  • To determine the efficacy of vitamin B6 repletion and megadosing on immune function.

Main Methods:

  • Review of animal and human studies examining vitamin B6's role in immunity.
  • Analysis of immune parameters such as lymphocyte differentiation, cell-mediated immunity, and antibody production.
  • Evaluation of vitamin B6 repletion and megadosing effects.

Main Results:

  • Vitamin B6 deficiency negatively impacts humoral and cell-mediated immunity.
  • Immune functions are restored with vitamin B6 repletion, with no additional benefit from megadoses.
  • Vitamin B6 status may influence tumor growth and disease progression.

Conclusions:

  • Vitamin B6 plays a crucial role in maintaining optimal immune function.
  • Deficiency is associated with immune dysregulation in vulnerable populations like the elderly, HIV-infected individuals, and those with uremia or rheumatoid arthritis.
  • Further research is needed to elucidate mechanisms and establish optimal intake levels for immune health.

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