Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Histogenesis of malignant lymphomas]

G Delsol1, P Brousset, D Schlaifer

  • 1Groupe d'étude des lymphomes malins et laboratoire d'anatomie pathologique, CHU Purpan, Toulouse.

La Revue Du Praticien
|September 1, 1993
PubMed
Summary

Advances in molecular biology and immunohistochemistry have refined the classification of malignant lymphomas. These techniques reveal complex cellular origins and potential viral roles in lymphoma development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future.

ESMO open·2021
Same author

Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Colocalization of BCL2-positive and -negative follicular lymphoma.

Leukemia·2014
Same author

Specific infiltration pattern of FOXP3+ regulatory T cells in chronic histiocytic intervillositis of unknown etiology.

Placenta·2012
Same author

Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.

Blood cancer journal·2012

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Context:

  • Malignant lymphomas are classified based on histogenesis and cellular differentiation markers.
  • Immunohistochemistry, monoclonal antibodies, and molecular biology have revolutionized lymphoma classification.
  • Lymphoproliferations typically retain characteristics of their normal cellular counterparts.

Purpose:

  • To explore the evolving concepts of malignant lymphoma histogenesis and classification.
  • To highlight the role of advanced techniques in understanding lymphoma origins.
  • To investigate the potential etiological contributions of viral agents.

Summary:

  • Modern techniques like immunohistochemistry and molecular biology have significantly advanced the understanding of malignant lymphoma histogenesis and classification.
  • While most lymphomas reflect normal B and T cell differentiation, complex lymphoid subpopulations with imperfectly characterized features exist.
  • In situ hybridization and PCR have implicated viruses such as Epstein-Barr virus, HTLV-1, and HHV-6 in the oncogenesis of malignant lymphomas.

Impact:

  • Provides a refined framework for classifying malignant lymphomas.
  • Identifies key technological advancements driving progress in lymphoma research.
  • Suggests potential viral targets for future etiological investigations and therapeutic strategies.

Related Experiment Videos