Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen processing: a critical factor in rational vaccine design

J W Yewdell1, J R Bennink

  • 1Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

Seminars in Hematology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serendipity strikes twice: the discovery and rediscovery of defective ribosomal products (DRiPS).

Cellular and molecular biology (Noisy-le-Grand, France)·2005
Same author

PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes.

Journal of virology·2004
Same author

A novel influenza A virus mitochondrial protein that induces cell death.

Nature medicine·2001
Same author

Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells.

Journal of virology·2001
Same author

Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.

Journal of virology·2001
Same author

Multiple paths for activation of naive CD8+ T cells: CD4-independent help.

Journal of immunology (Baltimore, Md. : 1950)·2001

T lymphocytes are key to immunity and rejection. This review covers how antigenic peptides are generated and presented by major histocompatibility complex (MHC) molecules for T-cell recognition.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • T lymphocytes are crucial for immune responses, including recognizing foreign and self-antigens.
  • T-cell recognition is major histocompatibility complex (MHC)-restricted, involving T-cell receptors interacting with peptide-MHC complexes.

Purpose of the Study:

  • To review recent advancements in understanding antigen processing.
  • To elucidate the mechanisms of peptide generation and delivery to MHC molecules.

Main Methods:

  • Review of current literature on antigen processing pathways.
  • Analysis of molecular interactions between T-cell receptors, peptides, and MHC molecules.

Main Results:

  • Detailed mechanisms of antigenic peptide generation within antigen-presenting cells.

Related Experiment Videos

  • Understanding of peptide delivery to appropriate MHC class I and II molecules.

    • Conclusions:

    • Significant progress has been made in defining the molecular basis of T-cell antigen recognition.
    • Further understanding of antigen processing is vital for immunity, autoimmunity, and transplantation research.