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Calcification in polycystic disease

R Kutcher, M Schneider, D H Gordon

    Radiology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Extensive calcifications in kidneys, liver, and spleen were observed in two patients with polycystic disease. These unique calcification patterns, including amorphous forms, are not previously reported in polycystic kidney disease.

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    Area of Science:

    • Nephrology
    • Radiology
    • Pathology

    Background:

    • Polycystic kidney disease (PKD) is a genetic disorder characterized by numerous cysts in the kidneys.
    • Calcifications are sometimes observed in PKD, typically as small flecks within cyst walls.
    • Extensive and varied calcification patterns in abdominal organs are not well-documented in PKD.

    Observation:

    • Two patients with diagnosed polycystic disease presented with significant calcifications.
    • Calcifications were noted in the kidneys, liver, and spleen.
    • Specific calcification morphologies included curvillinear, arcuate, and central amorphous patterns.

    Findings:

    • The observed calcifications in the kidneys, liver, and spleen were extensive and morphologically distinct.
    • Curvilinear, arcuate, and central amorphous calcifications associated with polycystic disease have not been previously reported.

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  • Dystrophic calcifications in these patterns may be indicative of polycystic disease, especially with superimposed hemorrhage or infection.

    • Implications:

    • Polycystic disease should be considered in the differential diagnosis for patients presenting with extensive abdominal calcifications.
    • Recognition of these calcification patterns may aid in earlier diagnosis or management of polycystic disease.
    • Further research is warranted to understand the pathogenesis of these extensive calcifications in PKD.