Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endocrine cells in diffuse pulmonary fibrosis

N J Wilson1, J R Gosney, F Mayall

  • 1Department of Pathology, University of Liverpool.

Thorax
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Australian Registered Nurse's' Awareness of Key Issues, Ambivalence and Education Related to the Health of People With Intellectual Disability and/or Autism.

Journal of applied research in intellectual disabilities : JARID·2025
Same author

Patient experiences during the planned perioperative care pathway: An integrative review.

Journal of advanced nursing·2024
Same author

Response to letter entitled: letter comments on: Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation.

ESMO open·2023
Same author

Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation.

ESMO open·2023
Same author

Training support workers about the overmedication of people with intellectual disabilities: an Australian pre-post pilot study.

Journal of intellectual disability research : JIDR·2023
Same author

Access to Sexual Health Services and Support for People with Intellectual and Developmental Disabilities: an Australian Cross-sector Survey.

Sexuality research & social policy : journal of NSRC : SR & SP·2022
Same journal

Mediastinal amyloidosis mimicking advanced lung cancer.

Thorax·2026
Same journal

Comparative performance of endobronchial ultrasound-guided sampling techniques in patients with mediastinal lesions: a network meta-analysis.

Thorax·2026
Same journal

Vitamin A and D impact on lung function: differential or common effects across the lifespan?

Thorax·2026
Same journal

The impact of vitamins A and D on lung function and regulatory epigenetics in adult and childhood asthma.

Thorax·2026
Same journal

Radiological factors associated with the recurrence of <i>Mycobacterium avium complex</i> pulmonary disease: a multicentre retrospective cohort study.

Thorax·2026
Same journal

Daughter vesicles in primary diaphragmatic hydatid cyst.

Thorax·2026
See all related articles

Pulmonary endocrine cells are not involved in human lung fibrosis. Their numbers decrease with fibrosis, likely due to general epithelial damage, not a specific role in disease pathogenesis.

Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Pathology

Background:

  • Gastrin-releasing peptide and other pulmonary endocrine cell products are suspected contributors to lung fibrosis.
  • Previous studies, primarily in animals, suggested a role for these cells in fibrotic lung disease pathogenesis.

Purpose of the Study:

  • To investigate the role of pulmonary endocrine cells in human diffuse pulmonary fibrosis.
  • To examine the morphology, number, distribution, and secretory content of these cells in fibrotic lung tissue.

Main Methods:

  • Studied lung tissue from 49 patients with varying stages of diffuse pulmonary fibrosis and 5 healthy controls.
  • Utilized immunolabeling techniques with general markers (protein gene product 9.5, neuron-specific enolase) and specific secretory products.

Related Experiment Videos

Main Results:

  • In early pneumonitis, endocrine cells were few but morphologically normal, containing only typical secretory products.
  • Endocrine cell numbers further decreased in early fibrosis.
  • No identifiable endocrine cells were found in lungs with honeycombing, despite preserved epithelium.

Conclusions:

  • Pulmonary endocrine cell products are unlikely to play a role in the pathogenesis of human diffuse pulmonary fibrosis.
  • The observed decrease in endocrine cells likely results from generalized epithelial damage during fibrosis progression.