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Hemostatic markers in acute transient ischemic attacks

E A Fon1, A Mackey, R Côté

  • 1Department of Neurology and Neurosurgery, Montreal General Hospital, McGill University, Quebec, Canada.

Stroke
|February 1, 1994
PubMed
Summary
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Early transient activation of thrombogenesis and ongoing fibrinolysis occur after acute reversible cerebral ischemia. This study assessed coagulation parameters in transient ischemic attack patients, revealing elevated markers in the acute phase.

Area of Science:

  • Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Hemostatic abnormalities are documented in stroke patients.
  • Understanding coagulation in transient ischemic attack (TIA) is crucial.

Purpose of the Study:

  • To evaluate coagulation system activity in acute reversible cerebral ischemia.
  • To assess specific markers like fibrinopeptide A, thrombin-antithrombin III, and D-dimer.

Main Methods:

  • Measured fibrinopeptide A, thrombin-antithrombin III, and D-dimer in 36 acute TIA patients.
  • Compared results with postacute TIA patients, remote TIA patients, and controls.
  • Assessed clinical outcome and cervical atherosclerosis correlation.

Main Results:

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  • Fibrinopeptide A and thrombin-antithrombin III were elevated in the acute TIA stage.
  • D-dimer remained significantly increased at all measured time points post-TIA compared to controls.
  • No correlation found between marker levels and clinical outcome or atherosclerosis.

Conclusions:

  • Acute reversible cerebral ischemia involves early, transient thrombogenesis activation.
  • Ongoing fibrinolysis is indicated by elevated D-dimer levels post-TIA.
  • Coagulation marker levels did not predict clinical outcome or atherosclerosis severity.