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Familial subarachnoid haemorrhage

I C Bailey1

  • 1Department of Neurosurgery, Royal Victoria Hospital, Belfast.

The Ulster Medical Journal
|October 1, 1993
PubMed
Summary

Familial subarachnoid hemorrhage, often from ruptured intracranial aneurysms, suggests a genetic link. Congenital arterial defects may increase the risk of early aneurysm rupture in affected families.

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Area of Science:

  • Neurology
  • Genetics
  • Vascular Surgery

Background:

  • Subarachnoid hemorrhage (SAH) is a serious neurological condition.
  • Intracranial aneurysms are a common cause of SAH.
  • Familial aggregation of SAH suggests a potential genetic predisposition.

Purpose of the Study:

  • To investigate the occurrence of familial subarachnoid hemorrhage.
  • To identify risk factors and patterns in families with multiple SAH cases.
  • To explore the association between congenital arterial defects and early aneurysm rupture.

Main Methods:

  • Retrospective review of 24 families identified between 1974 and 1992.
  • Analysis of patient demographics, aneurysm characteristics, and family history.
  • Clinical investigation of affected individuals.

Main Results:

  • Twenty-four families with multiple members experiencing SAH were identified over 19 years.
  • SAH cases occurred at a younger-than-average age.
  • Multiple intracranial aneurysms were frequently observed in affected individuals.

Conclusions:

  • The findings strongly suggest a hereditary component in subarachnoid hemorrhage.
  • Congenital arterial defects are implicated as a potential predisposing factor for early aneurysm rupture.
  • Early screening and genetic counseling may be beneficial for at-risk families.

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