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Related Experiment Videos

Bone marrow involvement in phenytoin induced 'pseudolymphoma'

J Singer1, C Schmid, R Souhami

  • 1Radiotherapy Department, University College Hospital, London, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|January 1, 1993
PubMed
Summary

Phenytoin can cause lymph node enlargement and bone marrow changes mimicking T-cell non-Hodgkin

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Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Drug-induced lymphadenopathy is a recognized phenomenon.
  • Phenytoin, an anticonvulsant, has been associated with various adverse effects, including hypersensitivity reactions.

Observation:

  • A patient presented with significant lymph node enlargement.
  • Bone marrow examination revealed changes suggestive of T-cell non-Hodgkin's lymphoma.

Findings:

  • The observed lymphadenopathy and bone marrow changes were attributed to phenytoin.
  • Discontinuation of phenytoin led to complete resolution of symptoms and hematologic abnormalities.

Implications:

  • This case highlights the importance of considering drug-induced lymphoproliferative disorders in the differential diagnosis.
  • Prompt recognition and withdrawal of the offending agent, phenytoin, can lead to favorable outcomes and avoid unnecessary treatment for lymphoma.

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