Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Enhanced robotic dissolution system with concurrent off-line analysis

O T Aloba¹, D E Bergman, R T Miller

¹Parke-Davis Pharmaceutical Research and Development, Warner-Lambert Co. Inc., Morris Plains, NJ 07950.

Journal of Pharmaceutical and Biomedical Analysis

|October 1, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factor IX inhibitors and anaphylaxis in haemophilia B.

Haemophilia : the official journal of the World Federation of Hemophilia·2016

Same author

Factor IX inhibitors and anaphylaxis in hemophilia B.

Haemophilia : the official journal of the World Federation of Hemophilia·2016

Same author

Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.

British journal of pharmacology·2014

Same author

A simple indentation device for measuring micrometer-scale tissue stiffness.

Journal of physics. Condensed matter : an Institute of Physics journal·2011

Same author

Arginase activity in mitochondria--An interfering factor in nitric oxide synthase activity assays.

Biochemical and biophysical research communications·2009

Same author

HIV infection changes glomerular podocyte cytoskeletal composition and results in distinct cellular mechanical properties.

American journal of physiology. Renal physiology·2006

Same journal

Analyzing the impact of ionizable lipid identity, purity, and stability on lipid nanoparticle performance.

Journal of pharmaceutical and biomedical analysis·2026

Same journal

Application of two-dimensional liquid chromatography as a complementary technique to circular dichroism spectroscopy and high-resolution mass spectrometry for the characterization of GalNAc-siRNA conjugates.

Journal of pharmaceutical and biomedical analysis·2026

Same journal

The transfer of per- and polyfluoroalkyl substances (PFAS) from mother to child: Comparison between maternal and cord blood in an Italian cohort.

Journal of pharmaceutical and biomedical analysis·2026

Same journal

UHPLC/Q-TOF-MS-based blood-component profiling and multi-omics analysis reveal potential protective mechanisms of Shenzhuo Formula against diabetic kidney disease.

Journal of pharmaceutical and biomedical analysis·2026

Same journal

Multi-center study of the recombinant cascade reagent (kinetic chromogenic assay) as an alternative method for bacterial endotoxin testing: Method validation, product suitability, and consistency evaluation with limulus amebocyte lysate.

Journal of pharmaceutical and biomedical analysis·2026

Same journal

Simultaneous enantioselective separation of 2-, 3- and 4-chloromethcathinones using supercritical fluid chromatography-tandem mass spectrometry and its application to human oral fluid samples.

Journal of pharmaceutical and biomedical analysis·2026

See all related articles

A modified robotic dissolution system integrates liquid chromatography (LC) for simultaneous sampling and analysis. This automated dual-tasking approach significantly improves operational efficiency and saves time in pharmaceutical testing.

Area of Science:

Analytical Chemistry
Automation in Pharmaceutical Analysis

Background:

Robotic systems offer automation benefits in pharmaceutical analysis.
Liquid chromatography (LC) is a standard technique for drug analysis.
Integrating dissolution testing with LC analysis can streamline workflows.

Purpose of the Study:

To integrate a liquid chromatography (LC) system with a Zymate II robotic dissolution system.
To develop a dual-tasking system for simultaneous dissolution sampling and LC analysis.
To evaluate the efficiency and accuracy of the integrated robotic system.

Main Methods:

Modification of a Zymate II robotic dissolution system with an Isco ISIS autosampler LC system.
Integration of LC system operation using Concurrent EasyLab programming.

Related Experiment Videos

Simultaneous dissolution sampling and LC analysis of standard and sample solutions.

Comparison of robotic and non-robotic dissolution data.

Validation of the quantitative LC method and system measurements.

Main Results:

The integrated system enabled simultaneous dissolution sampling and LC analysis.
Significant operational efficiency and time savings were achieved.
Robotic and non-robotic data showed good correlation with statistically insignificant differences (95% confidence level).
Validation confirmed linearity, precision, accuracy, and negligible carryover.

Conclusions:

The modified robotic dissolution system with integrated LC offers a highly efficient and time-saving solution for pharmaceutical analysis.
The dual-tasking system provides reliable and accurate results comparable to traditional methods.
This automation strategy enhances laboratory throughput and analytical performance.