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Determination of captopril in pharmaceutical samples by flow injection analysis
M I Albero1, C Sánchez-Petreño, M S García
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|October 1, 1993
Summary
A new flow injection spectrophotometric method accurately determines captopril. This technique measures the captopril-palladium complex absorbance, offering a rapid and precise analytical approach for pharmaceutical samples.
Area of Science:
- Analytical Chemistry
- Spectrophotometry
Background:
- Captopril is a widely used medication for hypertension and heart failure.
- Accurate and efficient methods are needed for captopril quantification in pharmaceutical formulations.
Purpose of the Study:
- To develop and validate a flow injection spectrophotometric method for captopril determination.
- To assess the method's applicability in analyzing pharmaceutical samples.
Main Methods:
- A flow injection analysis system was employed.
- Captopril was complexed with palladium(II) in a 0.12 M HCl medium.
- Absorbance was measured at 400 nm using spectrophotometry.
Main Results:
- The calibration graph demonstrated linearity within the concentration range of 2 x 10(-5) to 6 x 10(-4) M.
- The method achieved a high sampling frequency of 90 samples per hour.
- The method was successfully applied to determine captopril in real pharmaceutical samples.
Conclusions:
- The proposed flow injection spectrophotometric method is sensitive, rapid, and suitable for the routine determination of captopril in pharmaceutical products.
- This analytical approach offers an efficient alternative for quality control of captopril formulations.