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Apolipoprotein E to B ratio: a marker for type III hyperlipoproteinaemia
W März1, G Feussner, R Siekmeier
1Gustav Embden-Zentrum der Biologischen Chemie, J.W. Goethe-Universität, Frankfurt am Main, Germany.
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|November 1, 1993
Summary
The apolipoprotein E to apolipoprotein B ratio effectively identifies type III hyperlipoproteinaemia. This ratio offers high diagnostic sensitivity and specificity for screening familial dysbetalipoproteinaemia in clinical labs.
Area of Science:
- Clinical Biochemistry
- Lipid Metabolism
- Genetic Dyslipidemias
Background:
- Type III hyperlipoproteinaemia, also known as familial dysbetalipoproteinaemia, is a genetic disorder characterized by abnormal lipoprotein metabolism.
- Accurate diagnosis is crucial for effective management and prevention of cardiovascular complications.
Purpose of the Study:
- To evaluate the diagnostic utility of the apolipoprotein E to apolipoprotein B ratio in distinguishing type III hyperlipoproteinaemia from other hyperlipoproteinaemia types.
- To establish the sensitivity and specificity of this ratio as a screening tool.
Main Methods:
- Quantification of apolipoprotein B and apolipoprotein E levels in patients with type III hyperlipoproteinaemia and other hyperlipoproteinaemia types.
- Calculation of the apolipoprotein E/apolipoprotein B ratio and assessment of its discriminatory power.
- Determination of diagnostic sensitivity and specificity at a defined cut-off value.
Main Results:
- Patients with type III hyperlipoproteinaemia exhibited significantly higher apolipoprotein E and lower apolipoprotein B levels compared to other groups.
- The apolipoprotein E to apolipoprotein B ratio demonstrated strong discriminatory capability between type III and other hyperlipoproteinaemias.
- A cut-off ratio of 0.09 yielded a diagnostic sensitivity of 95% and specificity of 88%.
Conclusions:
- The apolipoprotein E to apolipoprotein B ratio is a highly effective and reliable biomarker for the initial screening of type III hyperlipoproteinaemia.
- This ratio serves as a valuable first-line diagnostic quantity in clinical laboratory settings for identifying familial dysbetalipoproteinaemia.