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Updated: Aug 19, 2026

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
Published on: June 12, 2020
[CT-guided biopsies of the axial skeleton. The approaches and results]
1Fachbereich Bildgebende Diagnostik, Deutsche Klinik für Diagnostik, Wiesbaden.
Abstract:
The value of percutaneous CT-guided biopsies of the axial skeleton for establishing a diagnosis is determined from a series of 75 punctures in 74 patients in retrospect. Indications showed benign conditions to prevail over malignant lesions by a ratio of 1.6:1. Biopsy routes turned out to be strongly determined by regional anatomy allowing for a standardised procedure in each area. 64 out of 75 histological diagnoses were confirmed by open surgery (n = 17) or follow-up (n = 58) accounting for an accuracy of 85.3%. In 7 cases no definite diagnosis could be made from the sample and in 4 cases the diagnosis proved false although tissue cores could be obtained in each case. No serious or irreversible complications occurred. CT-guided punctures of the axial skeleton are considered a safe and highly accurate procedure to establish a definite diagnosis unless there is a primary indication for surgery or the need for decompression.

