Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenytoin concentration elevation subsequent to ranitidine administration

C S Tse1, K I Akinwande, K Biallowons

  • 1Department of Pharmacy, St. James Hospital and Health Centers, Chicago Heights, IL 60411.

The Annals of Pharmacotherapy
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foreign language learning as potential treatment for mild cognitive impairment.

Hong Kong medical journal = Xianggang yi xue za zhi·2019
Same author

Editorial: biologic therapies for primary sclerosing cholangitis-more disappointment than promise? Authors' reply.

Alimentary pharmacology & therapeutics·2018
Same author

Effects of vedolizumab, adalimumab and infliximab on biliary inflammation in individuals with primary sclerosing cholangitis and inflammatory bowel disease.

Alimentary pharmacology & therapeutics·2018
Same author

Postoperative outcomes in vedolizumab-treated Crohn's disease patients undergoing major abdominal operations.

Alimentary pharmacology & therapeutics·2017
Same author

Validation of selective attention and memory measures as early markers for Alzheimer's disease.

Hong Kong medical journal = Xianggang yi xue za zhi·2016
Same author

The utility of a non-verbal prospective memory measure as a sensitive marker for early-stage Alzheimer's disease in Hong Kong.

International psychogeriatrics·2014
Same journal

Association Between Prior PARP Inhibitor Maintenance Therapy and Myelosuppression During Subsequent Chemotherapy in Ovarian Cancer.

The Annals of pharmacotherapy·2026
Same journal

Prolonged Response to Nivolumab in Metastatic Vulvar Carcinoma: Should Immunotherapy be Continued and for How Long? A Debatable Issue!

The Annals of pharmacotherapy·2026
Same journal

Stability of Ceftazidime-Avibactam: Changes in Regulatory Information and Implications for Preparation.

The Annals of pharmacotherapy·2026
Same journal

Impact of Early Dose Adjustment of Piperacillin/Tazobactam on Mortality in Critically Ill Patients With Acute Kidney Injury: A Retrospective Multicenter Cohort Study.

The Annals of pharmacotherapy·2026
Same journal

Severe Phototoxic Skin Reaction Associated With Vandetanib: Implications for Pharmaceutical Care.

The Annals of pharmacotherapy·2026
Same journal

Efficacy and Safety of Oral PCSK9 Inhibitors in Adults With Hypercholesterolemia: An Updated Systematic Review and Meta-Analysis of RCTs.

The Annals of pharmacotherapy·2026
See all related articles

Concurrent use of ranitidine may elevate phenytoin plasma concentrations. Monitoring is advised for patients taking both medications, as ranitidine may affect phenytoin metabolism.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy

Background:

  • Phenytoin (PHT) is an anticonvulsant medication with a narrow therapeutic index.
  • Ranitidine is a histamine H2-receptor antagonist commonly used to reduce stomach acid production.

Observation:

  • A patient on chronic phenytoin therapy experienced elevated PHT plasma concentrations after initiating ranitidine.
  • These elevated concentrations persisted for several days after phenytoin discontinuation and rapidly decreased following ranitidine withdrawal.

Findings:

  • The concurrent administration of ranitidine was associated with a significant increase in phenytoin plasma levels.
  • This interaction suggests a potential pharmacokineticImplication of ranitidine on phenytoin metabolism.

Implications:

Related Experiment Videos

  • Ranitidine may inhibit the cytochrome P-450 hepatic mixed-function oxidase system, affecting the metabolism of phenytoin.
  • Healthcare providers should consider this drug interaction and monitor phenytoin levels in patients concurrently using ranitidine.
  • A susceptible subpopulation may exist that is more prone to this ranitidine-phenytoin interaction.