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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
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Pulmonary tuberculosis due to bacille Calmette-Guérin

D Kirsten1, U Rieger, K H Schröder

  • 1Zentrum für Pneumologie, Krankenhaus Grosshansdorf.

The Clinical Investigator
|October 1, 1993
PubMed

Immunotherapy using bacille Calmette-Guérin (BCG) has gained increasing acceptance in the management of superficial bladder cancer. Systemic reactions after intravesical instillation of BCG are rare. However, when the therapy is complicated, the lung often becomes involved. Since the pathogenesis of lung infiltrates after immunotherapy is unknown, we report on a patient who developed a lung infiltrate after receiving BCG immunotherapy for bladder cancer. The infectious etiology was established by culture confirmation of a BCG strain in the bronchoalveolar lavage fluid.

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