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Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in northern India
1Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
Lupus
|October 1, 1993
Abstract:
Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.