Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vitro fertilization and embryo transfer: a randomized controlled trial

J F Jarrell1, R Labelle, R Goeree

  • 1Department of Obstetrics and Gynaecology, University of Calgary, Alberta, Canada.

The Online Journal of Current Clinical Trials
|July 2, 1993
PubMed
Summary

In vitro fertilization (IVF) increases pregnancy and live birth rates, but requires a longer patient commitment. This study compared IVF to delayed treatment, finding IVF effective despite longer patient involvement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linezolid resistance in coagulase-negative staphylococci.

The Journal of antimicrobial chemotherapy·2006
Same author

Batten disease: features to facilitate early diagnosis.

The British journal of ophthalmology·2006
Same author

Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG).

Annals of oncology : official journal of the European Society for Medical Oncology·2006
Same author

The seasonal fertility of North American bison (Bison bison) bulls.

Animal reproduction science·2006
Same author

Genome scan of schizophrenia families in a large Veterans Affairs Cooperative Study sample: evidence for linkage to 18p11.32 and for racial heterogeneity on chromosomes 6 and 14.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2005
Same author

Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review.

Human reproduction update·2005

Area of Science:

  • Reproductive Medicine and Endocrinology
  • Infertility Treatments
  • Clinical Trial Research

Background:

  • Clinical indications for in vitro fertilization (IVF) have broadened beyond tubal disease.
  • Spontaneous pregnancy cures are common in infertile couples.
  • The comparative effectiveness of IVF versus spontaneous cure or other fertility treatments lacks rigorous evaluation.

Purpose of the Study:

  • To evaluate the relative merit of in vitro fertilization (IVF) treatment compared to awaiting IVF treatment.
  • To assess clinical pregnancy rates and time to pregnancy in couples undergoing IVF.

Main Methods:

  • A randomized controlled clinical trial was conducted.
  • Couples seeking fertility treatment were randomized to either a control group (awaiting IVF) or an experimental group (undergoing IVF).

Related Experiment Videos

  • Clinical pregnancy rate and adjusted time to pregnancy were the primary outcome measures.

    • Main Results:

    • The intention-to-treat analysis revealed an increased proportion of pregnancies from 8% to 17.4% and parturitions from 4.9% to 11.6% in the experimental IVF group.
    • This increase in pregnancy rates with IVF required significantly more patient-time.
    • Survival analysis showed no significant difference in time-to-event between groups, though a long-term trend favored IVF.

    Conclusions:

    • In vitro fertilization (IVF) is effective in proportionally increasing pregnancy, live birth, and parturition rates.
    • The benefits of IVF are associated with a significantly longer patient commitment.
    • Further research is needed to conclusively assess long-term benefits, especially with variations in treatment access and patient selection.