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Related Experiment Videos

Comparison of four methods for calculating diffusing capacity by the single breath method

K C Beck1, K P Offord, P D Scanlon

  • 1Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905.

Chest
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

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Comparing four methods for measuring single-breath lung diffusing capacity for carbon monoxide (Dco), results showed small differences in Dco values. The Ogilvie, Jones-Meade, and three-phase iterative methods showed similar Dco in patients with lung abnormalities.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Accurate measurement of lung diffusing capacity for carbon monoxide (Dco) is crucial for diagnosing and managing respiratory diseases.
  • Several methods exist for calculating single-breath Dco, but their comparability, especially with automated equipment and standardized procedures, requires further investigation.

Purpose of the Study:

  • To compare the single-breath diffusing capacity of the lungs for carbon monoxide (Dco) measurements obtained using four different methods: Ogilvie (Og), Jones-Meade (JM), Epidemiological Standardization Project (ESP), and three-phase iterative (3PIT).
  • To assess the agreement between these methods across various degrees and patterns of pulmonary function abnormality.

Main Methods:

  • Single-breath Dco was measured in 283 patients using automated equipment and American Thoracic Society (ATS) recommended procedures.

Related Experiment Videos

  • Four calculation methods were employed: Ogilvie (Og), Jones-Meade (JM), Epidemiological Standardization Project (ESP), and three-phase iterative (3PIT).

    • Main Results:

    • Small but significant differences in mean Dco were observed, with ESP yielding the largest values, followed by JM, 3PIT, and Og.
    • The 3PIT and JM methods showed close agreement across all pulmonary function abnormalities.
    • The Og method showed a 6% lower Dco than JM in normal subjects, with less difference in patients with airflow limitation, restriction, or reduced Dco.
    • No significant differences in the reproducibility of Dco measurements were found among the methods.

    Conclusions:

    • When using automated equipment and ATS-recommended procedures, the ESP method yields the highest Dco, followed by JM, 3PIT, and Og.
    • For patients with reduced Dco due to obstructive or restrictive lung disease, the Og, 3PIT, and JM methods provide nearly equivalent results.
    • All tested methods demonstrate comparable reproducibility for Dco measurements.