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Nervous system dysfunction among workers with long-term exposure to manganese

D Mergler1, G Huel, R Bowler

  • 1Centre pour l'étude des interactions biologiques entre la santé et l'environnement (CINBIOSE), Université du Québec, Montréal, Canada.

Environmental Research
|February 1, 1994
PubMed
Summary

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Long-term manganese (Mn) exposure in alloy workers is linked to early nervous system dysfunction. Sensitive neurofunctional tests revealed deficits in motor skills and cognition, suggesting early manganism is detectable.

Area of Science:

  • Environmental Health
  • Neuroscience
  • Occupational Medicine

Background:

  • Neurological disorders, including Parkinson's disease-like symptoms, are associated with manganese (Mn) exposure.
  • Understanding early nervous system effects of occupational Mn exposure is crucial for worker health.
  • Manganese alloy production presents a significant occupational exposure risk.

Purpose of the Study:

  • To document early nervous system dysfunction in workers with long-term manganese exposure.
  • To assess neurofunctional changes in Mn alloy production workers compared to a matched control group.

Main Methods:

  • A matched pair study design involving 115 Mn alloy workers and referents.
  • Neurofunctional tests administered to assess various cognitive, motor, and sensory functions.

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  • Environmental and biological monitoring (whole blood and urinary Mn levels) conducted.

    • Main Results:

    • Mn alloy workers exhibited significantly higher whole blood Mn levels compared to controls.
    • Workers showed differences in symptom reporting, emotional state, motor functions, cognitive flexibility, and olfactory perception.
    • No significant differences were found in verbal fluency, basic mathematics, reading, or attentional capacity.

    Conclusions:

    • Early signs of manganism can be detected in occupational populations using sensitive neurofunctional testing.
    • The findings align with existing knowledge regarding manganese's impact on brain function.
    • This study highlights the importance of monitoring and intervention for workers exposed to manganese.