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Pure progressive autonomic failure: a clinicopathological study

Y Terao¹, K Takeda, M Sakuta

¹Department of Neurology, Japanese Red Cross Medical Center, Tokyo.

European Neurology

|January 1, 1993

Summary

Progressive autonomic failure (PAF) can rarely stem from central nervous system pathology, not just peripheral nerves. One case showed Parkinson

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Area of Science:

Neurology
Autonomic Neuroscience
Pathology

Background:

Progressive Autonomic Failure (PAF) is a neurodegenerative disorder affecting the autonomic nervous system.
Clinical presentation often suggests postganglionic sympathetic dysfunction.

Observation:

Two cases of pure PAF were analyzed.
A postmortem examination of one case revealed neuropathology similar to Parkinson's disease.

Findings:

Significant neuronal loss was observed in the substantia nigra, nucleus ceruleus, and spinal cord's intermediolateral column.
Sympathetic ganglion cell loss was not prominent in the examined case.

Implications:

This suggests PAF can, in rare instances, be linked to preganglionic or central nervous system pathology.

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Understanding the central role in PAF pathogenesis may refine diagnostic and therapeutic strategies.