Related Experiment Videos
A novel gene delivery system using EGF receptor-mediated endocytosis
J Chen1, S Gamou, A Takayanagi
1Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.
FEBS Letters
|January 31, 1994
Abstract:
A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.