Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Enhanced osteogenesis in severe aplastic anemia]

V M Ponomarenko, K M Abdulkadyrov, V I Rugal'

    Gematologiia I Transfuziologiia
    |June 1, 1993
    PubMed
    Summary

    Aplastic anemia (AA) is linked to increased spongy bone tissue and osteoid cells, suggesting heightened bone formation activity. This indicates a potential connection between bone development and blood cell production in AA patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Targeted therapy of polycytemia vera patients.

    Voprosy onkologii·2018
    Same author

    Role of molecular-genetic abnormalities in pathogenesis and risk stratification of multiple myeloma.

    Voprosy onkologii·2018
    Same author

    [Matrix metalloproteinase-9 in plasma of bone marrow aspirates of patients with acute myeloid leukemia and myelodysplastic syndrome].

    Voprosy onkologii·2018
    Same author

    [The specific features of diagnosis of mixed-phenotype acute leukemia: A combination of B-cell antigen expressions according to the results of flow cytometry and morphological markers of myeloid differentiation in blast cells: A clinical case].

    Terapevticheskii arkhiv·2015
    Same author

    [Heterogeneity of acute myeloid leukemia with the translocation t(8;21)(q22;q22)].

    Terapevticheskii arkhiv·2014
    Same author

    [The specific features of the immunophenotype of blast cells in patients with de novo normal karyotype acute myeloid leukemia and FLT3-ITD mutation].

    Terapevticheskii arkhiv·2014

    Area of Science:

    • Hematology
    • Orthopedics
    • Pathology

    Context:

    • Aplastic anemia (AA) is a rare but serious condition where the bone marrow doesn't produce enough blood cells.
    • Bone marrow microenvironment plays a crucial role in regulating hematopoiesis and bone remodeling.

    Purpose:

    • To investigate the histomorphometric changes in the bone marrow of patients with aplastic anemia.
    • To explore the potential relationship between osteogenesis and hemopoiesis in the context of AA.

    Summary:

    • Histologic examination of bone marrow from AA patients revealed increased spongy bone tissue and a higher number of osteoid cells compared to healthy controls.
    • These findings suggest enhanced proliferative activity of osteogenic precursors and increased osteosynthesis in AA.
    • The study posits a probable interrelationship between osteogenesis and hemopoiesis in aplastic anemia.

    Impact:

    • Provides insights into the bone marrow's structural alterations in aplastic anemia.
    • Suggests a potential link between bone metabolism and the hematopoietic dysfunction observed in AA.
    • May open new avenues for understanding the pathophysiology of AA and developing novel therapeutic strategies targeting bone-hematopoietic interactions.

    Related Experiment Videos