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Measurement of acetylcholine receptor function in microcircuit-coupled myoblasts
J N Quong1, T L Fare, H J Bryant
1Geo-Centers, Inc., Ft. Washington, MD.
IEEE Transactions on Bio-Medical Engineering
|November 1, 1993
Abstract:
An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.