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Amiloride inhibits arginine vasopressin-induced decrease in fetal lung liquid secretion

S Cassin1, A M Perks

  • 1Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1993
PubMed
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Arginine vasopressin (AVP) reduces fetal lung liquid secretion. Amiloride reversed this effect, suggesting AVP

Area of Science:

  • Fetal Physiology
  • Endocrinology
  • Pulmonary Medicine

Background:

  • Fetal lung liquid secretion is crucial for lung development.
  • Hormonal regulation of fetal lung fluid balance is not fully understood.
  • Arginine vasopressin (AVP) is a key hormone in fluid balance.

Purpose of the Study:

  • To investigate the effects of arginine vasopressin (AVP) on fetal lung liquid secretion.
  • To determine if amiloride can reverse AVP-induced changes in lung liquid secretion.
  • To explore the role of AVP in fetal lung fluid removal at birth.

Main Methods:

  • 16 unanesthetized fetal sheep (129-135 days gestation) were used.
  • Indwelling catheters were placed for infusions and measurements.
  • Lung liquid secretion was measured using an impermeant tracer technique.

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Main Results:

  • Control fetuses maintained a stable lung liquid secretion rate.
  • AVP infusion significantly decreased lung liquid secretion by 68% in the final hour.
  • Amiloride administration reversed the AVP-induced reduction in secretion.

Conclusions:

  • AVP plays a significant role in reducing fetal lung liquid secretion.
  • Amiloride can counteract the effects of AVP on lung fluid.
  • AVP, along with other stress hormones, may facilitate lung fluid removal during birth.