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Effect of common vasodilators on lung microvascular permeability
1Department of Physiology, James H. Quillen College of Medicine, Johnson City, Tennessee 37614-0576.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1993
Summary
Papaverine significantly increases albumin permeability and decreases endothelial selectivity in isolated rabbit lungs. This suggests caution when using papaverine in Ringer-perfused lung models.
Area of Science:
- Physiology
- Pharmacology
- Pulmonary Research
Background:
- Understanding the impact of pharmacological agents on lung microvascular function is crucial for interpreting experimental results.
- Papaverine is a vasodilator, but its specific effects on lung endothelial permeability are not fully elucidated.
Purpose of the Study:
- To investigate the effects of papaverine on albumin permeability-surface area product (PS), reflection coefficient (sigma), and capillary filtration coefficient (Kf) in isolated rabbit lungs.
- To compare papaverine's effects with other methods of maximizing lung surface area, such as isoproterenol and increased vascular pressure.
Main Methods:
- Isolated rabbit lungs were perfused with papaverine (0.1 mg/ml).
- Measurements of PS, sigma, and Kf were conducted.
- Comparisons were made with control groups, isoproterenol treatment, and increased vascular pressure.
Main Results:
- Papaverine significantly increased albumin permeability (PS) and decreased endothelial selectivity (sigma).
- Capillary filtration coefficient (Kf) was significantly lower after papaverine administration.
- Isoproterenol and increased vascular pressure did not increase Kf and PS, suggesting maximal lung recruitment.
Conclusions:
- Papaverine enhances albumin permeability and reduces the selectivity of the lung endothelium.
- The isolated perfused lung model appears fully recruited under baseline conditions.
- Caution is advised when using papaverine in Ringer-perfused lung preparations.