Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunological recognition in pregnancy: physiology]

D Vinatier1, J C Monnier

  • 1Maternité du Pavillon Victor-Olivier, Service de Gynécologie-Obstétrique, CHRU de Lille.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Autotransplantation of cryoconserved ovarian tissue: First experience in Universitary Hospital Center of Lille].

Gynecologie, obstetrique, fertilite & senologie·2019
Same author

[Immunological aspects of ovarian cancer: Therapeutic perspectives].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
Same author

How to improve the preoperative staging of presumed early-stage endometrioid endometrial cancer?

European journal of gynaecological oncology·2016
Same author

Pelvic endometriosis in women under 25: a specific management?

Minerva medica·2014
Same author

[Impact of preoperative breast magnetic resonance imaging on surgical management: experience of two university hospitals].

Gynecologie, obstetrique & fertilite·2014
Same author

[Trophoblast: conductor of the maternal immune tolerance].

Journal de gynecologie, obstetrique et biologie de la reproduction·2014

The maternal immune system balances pro- and anti-inflammatory cytokines to support pregnancy. Disturbances in this delicate cytokine network, influenced by fetal antigens like HLA-G, can lead to pregnancy complications.

Area of Science:

  • Reproductive immunology
  • Maternal-fetal interface immunology

Context:

  • Maternal immune tolerance of the semi-allogeneic fetus is crucial for successful pregnancy.
  • The trophoblast, expressing unique antigens like HLA-G, plays a key role in modulating maternal immune responses.
  • The feto-placental interface is a dynamic site of immune interaction.

Purpose:

  • To explore the immunological mechanisms governing maternal acceptance of the fetus.
  • To investigate the role of trophoblast antigens, particularly HLA-G, in immune modulation.
  • To understand the cytokine network's balance in maintaining pregnancy.

Summary:

  • Pregnancy involves complex maternal immune responses to fetal antigens, with trophoblast cells expressing unique molecules like HLA-G.
  • Initial inflammatory reactions at the feto-placental interface are followed by immunosuppressive mechanisms to prevent rejection.

Related Experiment Videos

  • A delicate equilibrium of cytokines, influenced by maternal and fetal factors, is essential for successful implantation and fetal development.

    • Impact:

    • Highlights the critical role of immune system regulation in successful gestation.
    • Identifies potential mechanisms underlying pregnancy pathologies linked to immune dysregulation.
    • Provides insights into the function of HLA-G and cytokine networks in reproductive success.