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Recurrent lymphocytic meningitis associated with hereditary isolated IgG subclass 3 deficiency
J A Snowden1, A Milford-Ward, L J Cookson
1Department of Infectious Diseases, Royal Hallamshire Hospital, Sheffield, U.K.
The Journal of Infection
|November 1, 1993
Summary
A young woman experienced recurrent lymphocytic meningitis. Investigations revealed a significant deficiency in Immunoglobulin G3 (IgG3), a condition also present in her father and brother, suggesting a potential genetic link.
Area of Science:
- Immunology
- Neurology
- Infectious Diseases
Background:
- Recurrent meningitis can stem from various causes, including immune deficiencies.
- Enteroviruses are a common cause of viral meningitis.
Observation:
- A young adult woman presented with three episodes of lymphocytic meningitis over five years, possibly enteroviral.
- Analysis revealed a sustained deficiency in Immunoglobulin G3 (IgG3) subclasses.
- Her father and brother exhibited a similar IgG3 deficiency.
Findings:
- The patient's recurrent meningitis was not explained by common associated conditions of IgG3 deficiency (e.g., respiratory or enteral infections).
- No other immune defects were identified.
- The findings suggest a potential role for IgG3 in defending against enteroviral meningitis.
Implications:
- This case highlights a potential, previously unrecognized association between isolated IgG3 deficiency and recurrent enteroviral meningitis.
- Further research is warranted to explore the specific role of IgG3 in enteroviral clearance and meningitis.
- Genetic factors may predispose individuals to both IgG3 deficiency and susceptibility to specific infections.