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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
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Factors affecting C3 in intestinal schistosomiasis

M M Hussein1, M M Ahmed, M Fayed

  • 1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Journal of the Egyptian Society of Parasitology
|December 1, 1993
PubMed

Insights

Complement component C3 (C3) levels are lower in individuals with schistosomiasis compared to healthy individuals. C3 levels were not significantly affected by Hepatitis B surface antigen (HBsAg) status or S. mansoni egg count.

Area of Science:

  • Immunology
  • Hepatology
  • Parasitology

Background:

  • Schistosomiasis is a parasitic disease affecting millions worldwide.
  • Complement component C3 (C3) plays a crucial role in immune responses.
  • Hepatitis B virus (HBV) infection is common in schistosomiasis-endemic areas.

Purpose of the Study:

  • To investigate complement component C3 (C3) levels in patients with schistosomiasis.
  • To explore the relationship between C3 levels, Schistosoma mansoni (S. mansoni) egg count, Hepatitis B surface antigen (HBsAg) presence, and liver function.

Main Methods:

  • Serum C3 levels were measured in schistosomal patients without obvious nephritis.
  • C3 levels were analyzed in relation to S. mansoni egg count, HBsAg status, and liver function tests.
  • Statistical analysis was performed to determine correlations and significant differences.

Main Results:

  • C3 levels were significantly lower in schistosomal patients compared to normal individuals.
  • C3 levels were low in both HBsAg-negative and HBsAg-positive patients.
  • No significant difference in C3 levels was observed based on HBsAg status or S. mansoni egg count (categorized as >400 or <400 eggs/1g).
  • Ascites presence did not affect C3 concentration.
  • A positive correlation was found between C3 and serum albumin levels.

Conclusions:

  • Complement component C3 (C3) levels are reduced in patients with schistosomiasis, irrespective of HBsAg status or S. mansoni egg burden.
  • Serum albumin may influence C3 levels in schistosomal patients.
  • Further research is needed to understand the implications of C3 dysregulation in schistosomiasis and its impact on liver function.

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