Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Controlled-release isosorbide dinitrate pellets. Part I: Design and evaluation of controlled-release capsule dosage

J K Lalla1, S U Bhat

  • 1Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Bombay, India.

Journal of Pharmaceutical Sciences
|December 1, 1993
PubMed
Summary

New 8-hour controlled-release isosorbide dinitrate capsules were developed. Storage studies revealed that temperature and humidity accelerate drug degradation, necessitating controlled packaging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macro invertebrate community from Sonamarg streams of Kashmir Himalaya.

Pakistan journal of biological sciences : PJBS·2011
Same author

Formulation of an HPMC gel drug reservoir system with ethanol-water as a solvent system and limonene as a penetration enhancer for enhancing in vitro transdermal delivery of nicorandil.

Skin pharmacology and physiology·2004
Same author

Clinical trials of ayurvedic formulations in the treatment of acne vulgaris.

Journal of ethnopharmacology·2001
Same author

Study of processing parameters influencing the properties of diltiazem hydrochloride microspheres.

Journal of microencapsulation·2001
Same author

Controlled-release isosorbide dinitrate pellets. Part II: In vivo studies.

Journal of pharmaceutical sciences·1993
Same author

Biodegradable microspheres of poly(DL-lactic acid) containing piroxicam as a model drug for controlled release via the parenteral route.

Journal of microencapsulation·1993

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Formulation Development

Background:

  • Isosorbide dinitrate is a vasodilator used for angina.
  • Developing controlled-release formulations improves therapeutic efficacy and patient compliance.
  • The need for stable, long-acting isosorbide dinitrate formulations is critical.

Purpose of the Study:

  • To design and evaluate 8-hour controlled-release isosorbide dinitrate capsules.
  • To assess the in vitro drug release characteristics.
  • To investigate the stability of the formulation under various storage conditions.

Main Methods:

  • Formulation of 20.0 mg and 40.0 mg isosorbide dinitrate capsules.
  • In vitro dissolution testing to evaluate drug release kinetics.

Related Experiment Videos

  • Accelerated stability studies at elevated temperatures (30°C, 40°C) and humidity (72%, 90%).

    • Main Results:

    • The developed capsules demonstrated 8-hour controlled-release properties.
    • Both temperature and relative humidity significantly accelerated the degradation of isosorbide dinitrate.
    • Degradation rates increased with higher temperatures and humidity levels.

    Conclusions:

    • The controlled-release isosorbide dinitrate capsules meet the desired release profile.
    • The formulation's stability is compromised by elevated temperature and humidity.
    • Controlled packaging conditions are essential during the manufacturing and storage of these capsules to ensure drug integrity.