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Related Experiment Videos

A measles outbreak among adolescents

L B Weiner, R M Corwin, P I Nieburg

    The Journal of Pediatrics
    |January 1, 1977
    PubMed
    Summary

    A 1975 measles outbreak affected 147 adolescents, with 35% inadequately vaccinated. This study questions the long-term effectiveness of measles immunity in adolescents.

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    Area of Science:

    • Epidemiology
    • Immunology
    • Public Health

    Background:

    • Measles outbreaks can occur even in populations with vaccination programs.
    • Adolescents represent a demographic susceptible to measles outbreaks.
    • Assessing vaccine effectiveness and duration of immunity is crucial for public health.

    Purpose of the Study:

    • To investigate a measles outbreak in adolescents in May 1975.
    • To analyze the vaccination status and history of affected individuals.
    • To evaluate the duration of protection conferred by measles vaccines.

    Main Methods:

    • Case identification through physician and school nurse reports.
    • Review of immunization records for 54 confirmed measles cases.
    • Analysis of vaccination types, timing, and co-administration with immune globulin.
    • Serological testing using hemagglutination-inhibition antibody titers.

    Main Results:

    • 147 adolescents (ages 12-19) were identified with measles.
    • One junior high school accounted for 131 cases.
    • Among 54 cases with records, 35% received live measles virus vaccine without immune globulin after one year of age.
    • Hemagglutination-inhibition antibody titers confirmed measles in 11 children.
    • No index case or intrafamilial secondary cases were identified.

    Conclusions:

    • The outbreak among seemingly immunized adolescents raises concerns about the duration of vaccine-induced protection.
    • Inadequate vaccination histories were noted in a significant portion of cases.
    • Further research is needed to understand waning immunity and optimize adolescent vaccination strategies.

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