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Mammalian gene evolution: nucleotide sequence divergence between mouse and rat

K H Wolfe1, P M Sharp

  • 1Department of Genetics, University of Dublin, Trinity College, Ireland.

Journal of Molecular Evolution
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Mouse and rat homologous genes show significant DNA sequence divergence, with variations in substitution rates and base composition. Molecular evolution rates on the X-chromosome are slower, suggesting a "male-driven" evolution in mammals.

Area of Science:

  • Genomics
  • Molecular Evolution
  • Comparative Genomics

Background:

  • Mammalian gene evolution provides insights into species divergence.
  • Understanding DNA sequence divergence between closely related species like mouse and rat is crucial for evolutionary studies.

Purpose of the Study:

  • To investigate the DNA sequence divergence between homologous protein-coding genes in mice and rats.
  • To characterize the variation in nucleotide and amino acid sequence identity across a large gene set.

Main Methods:

  • Comparative analysis of 363 homologous protein-coding genes (411 kilobases) between mouse and rat.
  • Quantification of nucleotide and amino acid sequence identity.
  • Analysis of synonymous and nonsynonymous substitution rates and silent-site base composition.

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Main Results:

  • Mouse and rat homologous genes exhibit 93.4% nucleotide and 93.9% amino acid sequence identity on average.
  • Significant variation in nonsynonymous and synonymous substitution rates among genes was observed.
  • Genes on the X-chromosome showed slower molecular evolution rates, consistent with male-driven evolution.

Conclusions:

  • Rodent gene evolution displays substantial variation in substitution rates and base composition.
  • Evidence suggests synonymous codon usage in rodent genes is not strongly selected.
  • The study provides a comprehensive dataset for understanding mammalian gene evolution.