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Prosthetic bladder: in vivo studies on an active negative-pressure-driven device
1Department of Urology, Mayo Clinic, Rochester, Minnesota 55905.
The Journal of Urology
|March 1, 1994
Summary
This study shows that an active alloplastic bladder prosthesis is well tolerated in dogs after cystectomy. Effective function maintained renal function, while dysfunction led to hydronephrosis, highlighting the importance of active bladder emptying.
Area of Science:
- Urology
- Biomedical Engineering
- Surgical Innovation
Background:
- Cystectomy necessitates bladder reconstruction.
- Current methods face challenges in restoring natural bladder function.
- Developing effective bladder prostheses is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the efficacy and safety of an active alloplastic bladder prosthesis in a canine model.
- To assess the impact of the prosthesis on renal function and upper urinary tract pressures.
- To investigate the functional characteristics and potential complications of the negative pressure bladder prosthesis.
Main Methods:
- Implantation of active alloplastic bladders in four dogs post-cystectomy.
- Monitoring of upper tract vacuum pressures and renal function.
- Percutaneous measurement of ureteral pressures at varying flow rates.
- Assessment for complications such as hydronephrosis and encrustation.
Main Results:
- The alloplastic bladder prosthesis was well tolerated, creating a functional vacuum.
- Renal function was preserved with effective prosthesis function.
- Hydronephrosis and renal deterioration occurred with impaired emptying, resolving upon restoration of function.
- Ureteral pressures remained low even at high flow rates, and no encrustation was observed.
Conclusions:
- Active negative pressure bladder prostheses are promising for urological reconstruction.
- Effective active emptying is critical for maintaining renal function and preventing complications.
- Further research is warranted to advance this technology in urology.