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[A case of elevated serum creatine-kinase after anesthesia]
K Tanabe1, T Ishiyama, A Suzuki
1Department of Anesthesia, Daiyuukai General Hospital, Ichinomiya.
Masui. the Japanese Journal of Anesthesiology
|January 1, 1994
Summary
Postoperative creatine kinase (CK) elevation after cerebral aneurysm surgery, linked to fever and dark urine, suggests sympathetic nervous system activation. This finding is crucial for understanding neurological event complications.
Area of Science:
- Neurology
- Anesthesiology
- Biochemistry
Background:
- Cerebral aneurysm surgery presents complex anesthetic challenges.
- Postoperative monitoring for complications like elevated creatine kinase (CK) is essential.
Observation:
- A 50-year-old male exhibited markedly elevated serum CK levels (5919 IU/L) post-cerebral aneurysm surgery.
- This elevation coincided with hyperthermia (>39.5°C) and port-wine colored urine.
Findings:
- Elevated CK levels normalized within six days post-surgery.
- Myocardial infarction, malignant hyperthermia, and drug effects were ruled out as causes.
Implications:
- The study suggests sympathetic nervous system stimulation secondary to cerebral bleeding may cause significant CK elevation.
- Increased skeletal muscle sarcolemma permeability is implicated in this phenomenon.
- This case highlights a potential biomarker for neurological complications post-neurosurgery.